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Genetic factors affecting receptor expression or downstream signaling may limit effectiveness

Proteolytic activation of latent PPOs with trypsin has been reported for broad bean PPO 46 , paraguaya peach PPO 47 , spinach PPO 48 , loquat fruit PPO 49 , beet root PPO 19 , grape PPO 50 and apple PPO 21

Biofactors 26 (3), 201208

More specifically, they noted that at least one subject's Central corneal endothelial cells (CEC) density measurement was not completed before enrollment, which was one of the enrollment criteria, and another enrolled subject had Intraocular pressure (IOP) that was outside the criteria

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Schisandrin A also modulated autophagy and inflammation in these models: it inhibited excessive oxidative and inflammatory responses (for example, by reducing markers of lipid peroxidation and suppressing microglial activation) and helped normalize autophagy-related proteins that are disrupted in PD (59)